ONCOINVENT & RADSPHERIN® - A Novel Alpha-Emitting and Non-Systemic Radiopharmaceutical Concept in Clinical Development

November 22, 2023

 

We are honored to host a 1-1 discussion with Anders Manson, CEO of Oncoinvent, who has led a robust career in the pharmaceutical industry and eventually assumed leadership roles in biotech. His experience includes CEO positions and spearheading global business development at Neo Pharma, focusing on licensing opportunities and acquisitions. Anders’ expertise spans various work environments, from large multinationals to smaller biotechs, underscoring the importance of comprehending diverse organizational landscapes.  

Strategic Management Approach and Promising Prospects in Radiopharmaceuticals 

Anders Manson prioritizes strategic initiatives, especially amid challenges like capital shortages and industry downturns. Despite the current biotech slump, Oncoinvent, specializing in radiopharmaceuticals, stands promising, evidenced by significant acquisitions and investor attention in this domain. The company's focus on developing the first alpha emitter in the market positions it well in addressing high unmet medical needs, particularly in peritoneal carcinomatosis cases. 

Innovative Approach of Radspherin® and Strategic Milestones for OncoInvent 

The lead asset, Radspherin®, distinguishes itself as a radiopharmaceutical utilizing alpha emission, offering localized treatment for cancers affecting body cavities. It provides a targeted approach for cancers like peritoneal metastasis, exhibiting potential in treating areas such as the pleura. 

The upcoming goal for Oncoinvent in the upcoming year centers around initiating phase 2b trials in Europe and the US for peritoneal metastasis from colorectal and ovarian cancers. Capital raising and exploring licensing or partnership deals for Radspherin are on the agenda, gearing up for potential phase three trials in underserved medical areas. 

  

Strategic Pillars and Clinical Advancements of OncoInvent's Radspherin 

The company's strategic foundation includes experienced personnel, choosing radium-224 as a radioactive source, and in-house GMP manufacturing and clinical operations in Oslo. Their robust safety profile demonstrated in clinical trials provides promising results in comparison to standard care. The focus on peritoneal metastasis and the unique targeting approach distinguishes Radspherin, opening avenues for potential expansion into various cancers affecting body cavities. 

  

Strategic Commercialization Goals and Financial Imperatives for OncoInvent 

Looking ahead, Oncoinvent plans for commercialization, estimating a billion-dollar sales potential with competitive pricing strategies. Seeking partnerships for global or regional commercialization, finding a partner with commercial infrastructure becomes pivotal, aligning with plans for conditional approval during Phase 3. Financially, around $50 million is crucial to reach a value inflection point, emphasizing the need for funding to sustain ongoing studies and future expansion. 

  

Radiopharmaceuticals' Appeal, Funding Prospects, and Radspherin's Clinical Potential 

The attractiveness of radiopharmaceuticals stems from their effectiveness and resistance resilience. Manson's optimism in raising capital despite industry challenges, along with interest in radiopharmaceuticals, provides hope for successful funding. Radspherin's uniqueness in targeting specific body cavities and its strong global IP protection position it as a potential game-changer in clinical practice if results persist through further trials.